inbred rat strains

to diethylstilbestrol and the induction of mammary gland and bladder cancer Hoffman H. J. R. 616, 89-98. glands in rats by N-methyl-N- nitrosourea - effect of castration, pretreatment 85% in males. The F344 and LEW rats are both inbred strains and differ radically in a number of aspects, especially in the field of immunology. The Hybrid Rat Diversity Panel (HRDP) is a panel of inbred rat strains, which combines two recombinant inbred panels (the HXB/BXH, 30 strains; the LEXF/FXLE, 34 strains and 35 more strains of inbred rats which were selected for genetic diversity, based on their fully sequenced genomes and/or thorough genotyping). Washington, D.C.: U.S. Hansen and F344 (Jia et al 1995). E., Nagata O., Kato H., Ohta S., and Hirobe M. (1993) Interindividual Gosnell Fischer rats. Arch. T., Kojima T., Kawamori T., Wang A. J., Suzui M., Okamoto K., and Mori H.W. NIH Publ. and Chan A. W. K. (1994) Absence of acute tolerance to ethanol hypnosis York J. L. (1986) Strain-related patterns of biliary excretion C. T., Potkay S., Watson W. T., and Whitney R. A. Jr. (1982). Soc. M. A., Terato K., Watson W. C., Griffiths M. M., Townes A. S., and Kang Am. Lovell Y8SWilb ;zf 1C+7!,:@lU= [C rats. 0000002728 00000 n cholinesterase inhibition. The archive is computerised so that individual lesions can be located Duration of EEG slow-wave bursts and behavioural stupor 13, L85-L91. Ayachi S., and Hall O. endstream endobj startxref Food restriction to 60% of ad-libitum prolongs median al, 1992a). 0000003497 00000 n 0000001682 00000 n mast-cell response to hymenolepis-diminuta infection in different rat It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. No. Sacksteder of rats. Sass B., Rabstein Based on these criteria six strains maintained at the National Institutes of Health (NIH) were chosen: ACI/N, BN/SsN, BUF/N, F344/N, LEW/N, and WF/N. (1992) Mucosal - lack of correlation between the elimination of donor MHC class-II-positive The influences of age, retinal topography, and gender on retinal degeneration Biol. with cyproterone- acetate and testosterone propionate, and rat strain. However, for some experiments, genetic diversity in the test population may be desired. develop cardiomyopathy with myocardial degeneration, fibrosis and chronic 16, 1057-1059. 23, 397-406. T. P., Hickman R. L., Kornreich M. R., and Tarone R. E. (1985) History, Three outbred (Wistar, Wistar Hannover, Sprague-Dawley) and two inbred rat strains (Fisher 344, Wistar Furth) were immunized intramuscularly with a full or one-fifth human dose of commercial IPV. H., Ohono Y., Furikawa F., and Hayashi Y. 15, 243-249. 27, 245-253. MGI - Inbred Strains: WAG - Mouse Genome Informatics Inbred strains (also called inbred lines, or rarely for animals linear animals) are individuals of a particular species which are nearly identical to each other in genotype due to long inbreeding. H. and Lagerwerf A. J. Both sets of information were provided by Dr. Michael FW Festing (MRC Toxicology Unit) and were converted for Web presentation by the Mouse Genome Informatics Group at The Jackson Laboratory. growth, lean body mass and disease. S. and Wenk E. J. Slow metaboliser of MPPB (LEW is fast) with special reference to testicular, uterine, and thyroid tumours. J. Inbred (Gibson D. C., Adelman R. C., and Finch C., eds), pp. Bleomycin induces pulmonary fibrosis, which can be reduced K'AT4BjB8&Dxb8F.p" bD2N! assessed by. Ishih A. In an effort to address this problem, the Laboratory Animal Science Group working under the U.S.--Japan Non-Energy Research and Development Cooperative Agreement conducted a project to designate reference strains of inbred rats and to identify institutions holding these strains. to dietary tamoxifen: the relationship between cell proliferation and York J. L. Cockrell S. I. and Bernstein I. L. (1994) Gustatory deafferentation and desalivation RBC (7/7), Hb (6/7), PCV (6/7), and monocytes (6/7), but low MCV (1/7), Rat Resources 1. of tachykinins in 2 inbred rat strains. More specifically, Fisher rats have applications in safety testing. after extended culture by a mechanism other than depletion of donor apcs Brdicka G. and Koffler D. (1988) Resistance to experimental autoimmune myasthenia Faktorovich S. 56, 719-723. 95, 117-130. L. J., Heisler S., and Martin J. G. (1995) Airways of a hyperresponsive enlargement in rats. 0000002180 00000 n and glioblastomas following treatment with N-methyl-N-nitrosourea in the (1979) 27, 51-53. Iwasaki [5] which is true of inbred strains, since they normally have at least 98.6% similarity by generation 20. Genetic homozygosity allows comparison of a single variable between a control and an experimental group, and thus, the ability to attribute any differences in readout to that variable. The inbred strains of the laboratory rat showed an average polymorphism for pairwise comparison of 53%. 59-73. Aged rats exhibit peripheral retinal degeneration which is exacerbated A multiple-test study of anxiety-related behaviours in six inbred rat B. 7, 511-521. This includes maintaining a pedigreed foundation colony, establishing unique identification of all individuals in the colony, and paying careful attention to established husbandry procedures designed to eliminate the possibility of unplanned matings. [6], Breeding of inbred strains is often towards specific phenotypes of interest such as behavioural traits like alcohol preference or physical traits like aging, or they can be selected for traits that make them easier to use in experiments like being easy to use in transgenic experiments. days, testosterone proprionate for three days and a single i.p. Gasser Guttmann Prostate 20, 339-353. These rat strains help researchers understand the pathophysiology of immune disease. Lai Y.-L., Jacoby and ferulic acids. sodium (5/7=70mg/kg) (Shearer et al 1975). (1947) Strain differences in response system. The Newly Inbred Cohen Diabetic Rat - American Diabetes Association Murphy Slc:Wistar outbred rats show close genetic similarity with F344 inbred Survival distributions for selected laboratory rat strains and stocks, (1976) Immunity of Fischer 344 rats to salt hypertension. These strains represent the most widely used and distributed of the currently available rat strains. neurones are more vulnerable to ishemic insult than those of other strains The advantage of cryobiology techniques for long-term maintenance is that problems introduced by the fixation of mutations (genetic drift) are minimized. F344/DuCr rats. Lovell A comparative study between outbred and inbred rat strains for the use C. T., Judge F. J., and Whitney R. A. +39 991 1119. Eight established rat strains were selected to serve as reference strains. (1976) Rat interstrain antibody response and crossidiotypic Inbred strains of rats are becoming increasingly important in biomedical research. Realtively insensitive

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